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Iindaba

Ngaba i-biomarker entsha yegazi inokuqikelela umngcipheko we-Alzheimer?

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Isifundo esitsha sibonisa ukuba i-astrocyte, uhlobo lweseli yengqondo, ibalulekile ekuqhagamshele i-amyloid-kunye namanqanaba okuqala kwi-TAU SOITOITOICLORT. IKarna Bartishevich / isitokhwe

  • I-Asstrocytes esebenzayo, uhlobo lweseli yengqondo, inokunceda izazinzulu ziqonde ukuba kutheni abanye abantu abanolwazi olusempilweni kunye needipozithi ze-alzheimer, njengeeproteri ze-Alzheimer.
  • Isifundo esingaphezulu kwe-1 000 abathathi-nxaxheba bajonga kwii-biomaskis kwaye bafumanisa ukuba i-Amyloid-β idityaniswe kuphela namanqanaba anyukayo eTau kubantu abaneempawu zokukhulisa i-astrocyte.
  • Iziphumo zibonisa ukuba i-astrocytes ibalulekile ekuqhagamshele i-amyloid-β kunye namanqanaba okuqala kwe-TAU POOITOOIGT, enokutshintsha indlela esiyichaza ngayo isifo se-Alzheimer's.

Ukuqokelelwa kwe-Amyloid Pleques kunye neeproteri zeTeud Tau kwiNgqondo kudala kuthathwe ukuba nguyena unobangela ophambiliIsifo sika-Alzheimer (intengiso).

Uphuhliso lweziyobisi luye luthathele ingqalelo ekujolise kulo i-Amyloid kunye neTau, ukutyeshela indima enokubakho kwezinye iinkqubo zobuchopho, njengenkqubo ye-neuroimmune.

Ngoku, uphando olutsha kwiDyunivesithi yasePittsburgh lubonisa ukuba i-Aststuste ibonisa ukuba iiseli zengqondo, zidlala indima ebalulekileyo ekuqinisekiseni ukuqhubela phambili kwe-alzheimer's.

Umthombo we-AstrocyTestrityzininzi kwizicubu zobuchopho. Ekwecaleni kwezinye iiseli ze-gelial, umhlali wamatyala owomzimba, i-astrocytes ixhasa ii-neurons ngokubanika izondlo, ioksijini, kunye nokukhuselwa kwii-pathogens.

Ngaphambili indima ye-astrocyte kunxibelelwano lwe-neronial icinywe kuba iiseli ze-GLIAL aziqhubeli umbane njengee-neurons. Kodwa iYunivesithi yeDyunivesithi yasePittsburg le ngcinga kwaye iyasibonisa ukukhanya kwendima ebalulekileyo ye-astrocyte kwimpilo yengqondo kunye nesifo.

Iziphumo ezifunyenweyo zapapashwa kwiUmthombo weMthombo weMithombo yeNdalo.

Uphando lwangaphambili luphakamisa ukuba kuphazamiseka kwiinkqubo zengqondo ngaphaya komthwalo we-amyloid, njengokunyusa ukuvuvukala kwengqondo, kunokudlala indima ebalulekileyo ekuqaliseni ukwehla ngokukhawuleza kwe-Alzheimer's.

Kolu phononongo lutsha, abaphandi baqhuba iimvavanyo zegazi kubathathi-nxaxheba abayi-1 000 abavela kwizifundo ezintathu ezahlukileyo ezibandakanya abantu abadala abasempilweni abanengqondo abanezempilo kwaye ngaphandle kokwakha i-Amyloid.

Bahlalutya iisampulu zegazi ukuvavanya i-biomarkers ye-Astrocyte Reaves, ngokukodwa i-fibrillary ye-fibrillary ye-acidic (GFAP), ngokudibeneyo nobukho be-theudical tau.

Abaphandi bafumanisa ukuba kuphela abo banomthwalo we-amyloid kunye nabaphawu lwegazi ababonisa i-Astromal Asstracyte Asstracyte okanye ukuKhangela kusenokwenzeka ukuba kuphuculwe i-alzheimer ye-Alzheimer kwixesha elizayo.


IXESHA LOKUQALA: IJuni-08-2023